I think I found the issue:
Make a right click - properties to the PSU.vPilot2.dll
Check for the Security details. For me it was enabled and the "Unblock" button was shown.
As soon as I clicked it, and restarted vpilot, it was working again.
For doublecheck, I removed the .xml config file from the vpilot plugins sub folder and reentered the connections again.
It also worked.
greetings from Vienna / Austria